Betamethasone 17-valerate by aerosol in childhood asthma

Frears, J. F., Wilson, L. C., and Friedman, M. (1973). Archives of Disease in Childhood, 48, 856. Betamethasone 17-valerate by aerosol in childhood asthma. A double-blind cross-over trial of betamethasone 17-valerate (B17V) administered by aerosol was carried out by alternating two placebo periods with two treated periods at monthly intervals in 20 children with severe asthma. During the trial, the average of twice-daily peak expiratory flow readings was significantly increased in every child during actively treated months, compared with placebo months. Every child had fewer symptoms while using B17V, and the average reduction for the group as a whole was 71 %. Very much less additional medication for asthma was required during months of active treatment. The observed clinical response to therapy was dramatic in over halfthe children. No side effects were noted. Under the conditions of this study, we conclude that B17V by aerosol appears to be safe, and is effective for the control of asthma in children.